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09-066

Sigma-Aldrich

Anti-ASPM Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Abnormal spindle protein homolog, Asp homolog, asp (abnormal spindle) homolog, microcephaly associated (Drosophila), asp (abnormal spindle)-like, microcephaly associated, asp (abnormal spindle)-like, microcephaly associated (Drosophila), microcephaly, pr

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human

species reactivity (predicted by homology)

chimpanzee, primate

technique(s)

ELISA: suitable
immunohistochemistry: suitable

NCBI accession no.

NP_060606

UniProt accession no.

Q8IZT6

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ASPM(259266)

General description

The ASPM gene is the human ortholog of the Drosophila melanogaster ′abnormal spindle′ gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.

Specificity

This antibody recognizes ASPM.

Immunogen

KLH-conjugated linear peptide corresponding to human ASPM.

Application

Anti-ASPM Antibody detects level of ASPM & has been published & validated for use in IH, ELISA.
ELISA: Tested in direct ELISA against the ASPM immunogen.
Research Category
Signaling
Research Sub Category
Cell Cycle, DNA Replication & Repair

Quality

Immunohistochemistry Analysis: 1:300 dilution of this antibody detected ASPM in human ductal carcinoma tissue.

Target description

218, 95, 75 kDa Observed UniProtKB/Swiss-Prot entry Q8IZT6 describes 2 isoforms produced by alternative splicing: Isoform 1 at 409.800kDa and Isoform 2 at 217.794kDa Multiple other isoforms in ref: Human Molecular Genetics, 2005, Vol. 14, No. 15 2155–2165.

Physical form

Affinity purified
Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human ductal carcinoma tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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