178479
Anti-Apolipoprotein E Goat pAb
liquid, Calbiochem®
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About This Item
UNSPSC Code:
12352203
Recommended Products
biological source
goat
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, rat, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Anti-Apolipoprotein E, goat polyclonal, recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins. It is validated for ELISA, immunoprecipitation, and free-floating sections.
Goat polyclonal antibody supplied as serum that has been defibrinated, delipidized and dialyzed against a Tris-HCl buffer. Recognizes the apolipoprotein E protein.
Recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins.Antibody Target Gene Symbol: APOE Target Synonym: AD2, AI255918, APOE2, APOE4, APOEA, APOLIPOPROTEIN E, LDLCQ5, LPG, MGC1571 Entrez Gene Name: apolipoprotein E Hu Entrez ID: 348 (Related Antibodies: NE1004) Mu Entrez ID: 11816 Rat Entrez ID: 25728
Immunogen
Human
purified recombinant human apolipoprotein E
Application
ELISA (1:8000)
Immunoprecipitation (see comments)
Free Floating Sections (see application references)
Immunoprecipitation (see comments)
Free Floating Sections (see application references)
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Monospecific as determined by immunoelectrophoresis (IEP) against twice concentrated pooled human serum. This antibody has also been reported to work with immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Emilie L Castranio et al.
Neurobiology of disease, 105, 1-14 (2017-05-16)
Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset
Suzanne E Wahrle et al.
The Journal of biological chemistry, 279(39), 40987-40993 (2004-07-23)
ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids onto high density lipoproteins (HDL) in plasma. Lack of ABCA1 in humans and mice causes abnormal lipidation and increased catabolism of HDL, resulting in very low plasma apoA-I
Michael Landowski et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3703-3711 (2019-02-28)
One of the strongest susceptibility genes for age-related macular degeneration (AMD) is complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved. Here, the effect of the principal AMD-risk-associated CFH variant (Y402H) on the development and progression of
Ema Ozaki et al.
Experimental eye research, 217, 108953-108953 (2022-01-30)
As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal diseases. The semi-synthetic tetracycline antibiotic, minocycline, appears to inhibit
Shan-May Yong et al.
Scientific reports, 4, 6580-6580 (2014-10-11)
The effect of ApoE on NMDAR-dependent ERK/CREB signaling is isoform-dependent, and ApoE4 accelerates memory decline in ageing. However, this isoform-dependent function on neuronal signaling during ageing is unclear. In this study, we have examined NMDAR-associated ERK/CREB signal transduction in young
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