196810
Bax-Inhibiting Peptide, V5
A cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection.
Synonym(s):
Bax-Inhibiting Peptide, V5, BIP-V5, H-VPMLK-OH
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About This Item
Empirical Formula (Hill Notation):
C27H50N6O6S
Molecular Weight:
586.79
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 1 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection. Functions as effectively as the Caspase Inhibitor VI (Z-VAD-FMK; Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also effectively blocks caspase-independent necrotic cell death. Shown to be Ku70 competitive, interact with Bax, prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days). Negative control peptide is also available (Cat. No. 196811).
A cell-permeable pentapeptide derived from the Ku70-Bax inhibiting domain that has been shown to offer protection against apoptosis in cells of human, mouse, rant, and porcine origin. Reported to function as effectively as the caspase inhibitor, Z-VAD-FMK (Caspase Inhibitor VI, Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also reported to effectively block caspase-independent necrotic cell death. Shown to interact with Bax in a Ku70-competitive manner and prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Bax mediated apoptosis
Bax mediated apoptosis
Product does not compete with ATP.
Reversible: no
Target IC50: 50-200 µM against Bax mediated apoptosis
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
H-Val-Pro-Met-Leu-Lys-OH
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Storage in glass vials is not recommended as loss of activity may occur.
Other Notes
Yoshida, T., et al. 2004. Biochem. Biophys. Res. Commun.321, 961.
Sawada, M., et al. 2003. Nature Cell Biol.5, 352.
Sawada, M., et al. 2003. Nature Cell Biol.5, 352.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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