218773
Caspase-8 Inhibitor I, Cell-Permeable
The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Caspase-8 Inhibitor I, Cell-Permeable, Granzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable
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About This Item
Empirical Formula (Hill Notation):
C95H162N20O26
Molecular Weight:
2000.42
UNSPSC Code:
12352200
Recommended Products
Quality Level
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.
Potent, cell-permeable and reversible inhibitor of caspase-8 and Granzyme B.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-8
caspase-8
Product does not compete with ATP.
Reversible: yes
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.
Hamada, E., et al. 1990. J. Hepatol. 30, 807.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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