219404
Cathepsin H, Human Liver
Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.
Synonym(s):
Cathepsin H, Human Liver, CTSH, cat H, procathepsin h
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About This Item
CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.77
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Quality Level
form
liquid
specific activity
≥200 mU/mg protein
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
technique(s)
activity assay: suitable
color
colorless
pH
4.5
solubility
soluble
water: soluble
suitability
suitable for Western blot
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... CTSH(1512)
General description
Research area: Cell signaling
Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.
Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.
Application
Cathepsin H has been used to determine the potential of aziridinyl peptides to act as inhibitors of this protein and potentially explore their therapeutic applications.
Biochem/physiol Actions
Cathepsin H, derived from human liver, serves dual functions as both an aminopeptidase and an endopeptidase. It plays a significant role in the catabolism of proteins within lysosomes. Cathepsin H is classified as an endoaminopeptidase because it can hydrolyze proteins, N-terminal substituted proteins, amino acid derivatives, and peptides with different chain lengths and N-terminal free amino acid derivatives. This protein is also observed to exhibit amidase and esterase activity.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol H-Arg-βNA per min at 40°C, pH 6.8.
Physical form
In 100 mM NaCl, 20 mM sodium acetate buffer, 1 mM EDTA, pH 4.5.
Preparation Note
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Note: 1 mU = 1 milliunit.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK 2
Certificates of Analysis (COA)
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