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239824

Sigma-Aldrich

CXCR7 Agonist, VUF11207

The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

CXCR7 Agonist, VUF11207, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist

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About This Item

Empirical Formula (Hill Notation):
C27H35FN2O4
CAS Number:
1378524-41-4
Molecular Weight:
470.58
MDL number:
MFCD23136023
UNSPSC Code:
12352200

Quality Level

100

assay

≥99% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(N(CCC1N(C)CCC1)C/C(C)=C/C2=C(F)C=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3

General description

A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
CXCR7
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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