442630-M
GMBS
Synonym(s):
GMBS, N-γ-Maleimidobutyryloxysuccinimide
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About This Item
Empirical Formula (Hill Notation):
C12H12N2O6
CAS Number:
Molecular Weight:
280.23
MDL number:
UNSPSC Code:
12161500
NACRES:
NA.24
Recommended Products
assay
≥90% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
storage temp.
−20°C
InChI
1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
InChI key
PVGATNRYUYNBHO-UHFFFAOYSA-N
General description
Heterobifunctional reagent useful for preparation of conjugates such as secondary antibodies and β-galactosidase for EIA procedures or for immobilizing enzymes on solid supports.
N-γ-maleimidobutyryloxysuccinimide ester (GMBS) is an aliphatic crosslinker for immunotoxins (IT).(1) It is used for the generation of conjugated Poly-γ-D-glutamic acid.
Application
GMBS is suitable for use:
- as a hetero-bifunctional cross-linking reagent for the immobilization of neural adhesion molecule L1 onto silicon dioxide surface
- for the crosslinking of biochips with functionalized gold nanoparticles
- for coating salinized capillary tube prior to neutravidin treatment in biosensor sandwich immunoassay
Warning
Toxicity: Irritant (B)
Reconstitution
Reconstitute to 10 mg/ml in tetrahydrofuran or DMSO. Add 1 ml of this stock solution dropwise, with stirring, to 10 ml of 20 mM phosphate buffer.
Other Notes
Rusin, K.M., et al. 1992. Biosens. Bioelectron. 7, 367.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.
Kitagawa, T., et al. 1983. J. Biochem. 94, 1160.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization
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