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5.04120

Sigma-Aldrich

Reboxetine Mesylate

Synonym(s):

Reboxetine Mesylate, (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine methanesulfonate, Edronax, Vestra

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3 · xCH4O3S
CAS Number:
98769-84-7
Molecular Weight:
313.39 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

color

white

solubility

water: 20 mg/mL

storage temp.

2-8°C

InChI

1S/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1

InChI key

CGTZMJIMMUNLQD-STYNFMPRSA-N

General description

A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

Biochem/physiol Actions

Primary Target
Noradrenalin transporter
Target Ki: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.

Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markHealth hazard
GHS07,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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