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5.05816

Sigma-Aldrich

Xanomeline Oxalate

Synonym(s):

Xanomeline Oxalate, 3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole, Muscarinic Acetylcholine Receptor (mAChR) Agonist, Xanomeline

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About This Item

Empirical Formula (Hill Notation):
C14H23N3OS · xC2H2O4
CAS Number:
Molecular Weight:
281.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥99% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mM
ethanol: 25 mM

storage temp.

2-8°C

InChI

1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6)

InChI key

ZJOUESNWCLASJP-UHFFFAOYSA-N

General description

An agonist selective for muscarinic acetylcholine receptor (mAChR) subtype M1 (EC50 = 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). An antipsychotic agent. Used in improving cognitive deficits and behavioral disturbances in Alzheimer′s disease and schizophrenia.

Warning

Toxicity: Standard Handling (A)

Other Notes

Wang, D., et al., 2011. Biochem. Biophys. Res. Commun.410, 229.
Si, W., et al., 2010. Neurosci. Lett.473, 115.
Stanhope, et al., 2001. J. Exp. Pharmacol. Ther.299, 782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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