Skip to Content
MilliporeSigma
All Photos(1)

Documents

5.06125

Sigma-Aldrich

Paroxetine Hydrochloride

Synonym(s):

Paroxetine Hydrochloride, 5-HT transporter, Paroxetine, Paxil

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H20FNO3 · xHCl
CAS Number:
110429-35-1
Molecular Weight:
329.37 (free base basis)
UNSPSC Code:
12352200

assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

0.065 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: soluble

storage temp.

2-8°C

InChI

1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1

InChI key

AHOUBRCZNHFOSL-YOEHRIQHSA-N

General description

A very potent uptake inhibitor highly selective for 5-HT transporter (Ki = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.

Biochem/physiol Actions

Primary Target
5-HT Uptake Transporter

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.
Bourin, M., et al. 2001. CNS Drug Rev.7, 25.
Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service