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5.06239

Sigma-Aldrich

Bupropion Hydrochloride

Synonym(s):

Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion

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About This Item

Empirical Formula (Hill Notation):
C13H18ClNO · xHCl
CAS Number:
31677-93-7
Molecular Weight:
239.74 (free base basis)
MDL number:
MFCD00055209
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥99% (HPLC)

Quality Level

100

form

solid

potency

1.4 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: soluble

storage temp.

2-8°C

InChI

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

InChI key

HEYVINCGKDONRU-UHFFFAOYSA-N

General description

A non-selective inhibitor of dopamine and noradrenalin transporters (Ki = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC50 = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Biochem/physiol Actions

Primary Target
DAT/NET

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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