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516566

Sigma-Aldrich

PPARγ Antagonist III, G3335

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

Synonym(s):

PPARγ Antagonist III, G3335, H-Trp-Glu-OH

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About This Item

Empirical Formula (Hill Notation):
C16H19N3O5
CAS Number:
36099-95-3
Molecular Weight:
333.34
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 30 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1

InChI key

PWIQCLSQVQBOQV-AAEUAGOBSA-N

General description

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (KD = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.
A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PPARγ
Product does not compete with ATP.
Reversible: yes
kd = ~ 8 µM as PPARγ antagonist

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Addition of a small amount of acid or base may be required for complete solubilization.

Reconstitution

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ye, F., et al. 2006. Chembiochem7, 74.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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