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524748

Sigma-Aldrich

PDE4D Inhibitor, GEBR-7b

The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Synonym(s):

PDE4D Inhibitor, GEBR-7b, GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime

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About This Item

Empirical Formula (Hill Notation):
C21H30N2O5
CAS Number:
1349848-90-3
Molecular Weight:
390.47
MDL number:
MFCD28053503
UNSPSC Code:
12352200

Quality Level

100

assay

≥95% (HPLC)

form

semisolid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 100 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1

General description

A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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