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561300

Sigma-Aldrich

E-Selectin, Human, Recombinant, CHO Cells

Synonym(s):

CD62E, ELAM-1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

assay

≥95% (SDS-PAGE)

Quality Level

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

<1 EU/μg Endotoxin (EU/μg of E-Selectin)

shipped in

wet ice

storage temp.

−20°C

General description

Recombinant, human E-selectin consisting of 535 amino acids minus the transmembrane and cytoplasmic domains expressed in CHO cells. This glycoprotein is transiently expressed on vascular endothelial cell surfaces where it is able to bind to ligands such as SLex found on leukocytes. This initial binding event is followed by a second interaction involving ICAM and VCAM-1 that leads to vascular penetration and leukocyte invasion into the extracellular matrix tissue.
Recombinant, human E-selectin consisting of 535 amino acids minus the transmembrane and cytoplasmic domains expressed in CHO cells. This glycoprotein is transiently expressed on vascular endothelial cell surfaces where it is able to bind to ligands, such as sialyl Lewis x found on leukocytes. This initial binding event is followed by a second interaction involving ICAM and VCAM-1 that leads to vascular penetration and leukocyte invasion into the extracellular matrix tissue.

Biochem/physiol Actions

Shown to bind to E-selectin ligands on U937 cells.

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from Dulbecco′s PBS with stabilizer.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Reconstitute to 1 mg/ml with sterile H₂O.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 2


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