569406
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).
Synonym(s):
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
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About This Item
Empirical Formula (Hill Notation):
C19H18F3N5OS
Molecular Weight:
421.44
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3 nM. In vivo, it exhibits an ED50 of 1-3 mg/kg, p.o., in mouse liver PD assays.
Warning
Toxicity: Standard Handling (A)
Other Notes
Leger, S., et al. 2010. Bioorg Med Chem Lett.2, 499.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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