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Sigma-Aldrich

Syk Inhibitor III

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene

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About This Item

Empirical Formula (Hill Notation):
C9H7NO4
CAS Number:
1485-00-3
Molecular Weight:
193.16
MDL number:
MFCD00014575
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (GC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow to brown

solubility

DMSO: 25 mg/mL (Use only fresh DMSO.)

shipped in

ambient

storage temp.

−20°C

InChI

1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-

InChI key

KFLWBZPSJQPRDD-ARJAWSKDSA-N

General description

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Syk
Product does not compete with ATP.
Reversible: no
Target IC50: 2.5 µM against Syk kinase activity

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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