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574775-M

Sigma-Aldrich

Swainsonine, Swainsona canescens

Reversible active-site inhibitor of lysosomal α-mannosidase.

Synonym(s):

Swainsonine, Swainsona canescens, (1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol

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About This Item

Empirical Formula (Hill Notation):
C8H15NO3
CAS Number:
72741-87-8
Molecular Weight:
173.21
MDL number:
MFCD00017554
UNSPSC Code:
51101500

Quality Level

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 1 mg/mL
DMSO: 5 mg/mL
chloroform: soluble

storage temp.

2-8°C

InChI

1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1

InChI key

FXUAIOOAOAVCGD-WCTZXXKLSA-N

General description

Reversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.

Biochem/physiol Actions

Primary Target
Lysosomal α-mannosidase

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol.98, 135.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

Certificates of Analysis (COA)

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