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616400-M

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Tranilast

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

Synonym(s):

Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid

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About This Item

Empirical Formula (Hill Notation):
C18H17NO5
CAS Number:
53902-12-8
Molecular Weight:
327.33
MDL number:
MFCD00864787
UNSPSC Code:
51111800

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 200 mg/mL

storage temp.

−20°C

InChI

1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChI key

NZHGWWWHIYHZNX-CSKARUKUSA-N

General description

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.

Biochem/physiol Actions

Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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