Skip to Content
MilliporeSigma
All Photos(1)

Documents

648485-M

Millipore

TrpA1 Antagonist, HC-030031

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

TrpA1 Antagonist, HC-030031, HC-030031

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H21N5O3
CAS Number:
349085-38-7
Molecular Weight:
355.39
MDL number:
MFCD02007349
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL, clear, colorless

storage temp.

2-8°C

InChI

1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

InChI key

HEQDZPHDVAOBLN-UHFFFAOYSA-N

General description

A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.

Warning

Toxicity: Standard Handling (A)

Other Notes

Taylor-Clark, T., et al. 2008. Mol. Pharmacol.73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A.104, 13525.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service