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681636-M

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W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

Synonym(s):

W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

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About This Item

Empirical Formula (Hill Notation):
C14H17ClN2O2S · xHCl
CAS Number:
Molecular Weight:
312.81 (free base basis)
MDL number:
UNSPSC Code:
12352200

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 35 mg/mL

storage temp.

2-8°C

InChI

1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H

InChI key

QKAALLVQBOLELJ-UHFFFAOYSA-N

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).

Biochem/physiol Actions

Target IC50: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

Warning

Toxicity: Standard Handling (A)

Analysis Note

single spot by TLC

Other Notes

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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