AB1253
Anti-Cytochrome P450 Enzyme CYP3A1 Antibody
serum, Chemicon®
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
rat ... Cyp3A23-3A1(25642)
Specificity
Reacts with rat cytochrome P450 enzyme CYP3A1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A2.
Immunogen
Synthetic peptide
Application
Research Category
Metabolism
Metabolism
Research Sub Category
Enzymes & Biochemistry
Enzymes & Biochemistry
This Anti-Cytochrome P450 Enzyme CYP3A1 Antibody is validated for use in IH, WB for the detection of Cytochrome P450 Enzyme CYP3A1.
Western blot
Immunohistochemistry on formaldehyde treated sections.
Optimal working dilutions must be determined by end user.
Immunohistochemistry on formaldehyde treated sections.
Optimal working dilutions must be determined by end user.
Physical form
Rabbit antiserum. Liquid. Contains no preservative.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
Daniel L Gustafson, Michael E Long, Erica L Bradshaw, Andrea L Merz, Patrick J Kerzic
Cancer Chemotherapy and Pharmacology null
Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
Debri, K, et al.
Biochemical Pharmacology, 50, 2047-2056 (1995)
F P Guengerich
Annual review of pharmacology and toxicology, 39, 1-17 (1999-05-20)
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Er-Jia Wang,George Mandakas,Jairam Palamanda,Xinjie Lin,Pramila Kumari,Inhou Chu et al.
Drug and Chemical Toxicology null
Alterations in P-glycoprotein expression in mouse tissues by doxorubicin: implications for pharmacokinetics in multiple dosing regimens.
D L Gustafson, M E Long
Chemico-Biological Interactions null
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