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AB1871

Sigma-Aldrich

Anti-Caspase 1 Antibody

Chemicon®, from rabbit

Synonym(s):

ICE

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_001223.3
NM_033292.2
NM_033293.2
NM_033294.2
NM_033295.2

UniProt accession no.

P29466

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CASP1(834)
mouse ... Casp1(12362)
rat ... Casp1(25166)

General description

Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a proenzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits.

Specificity

AB1871 recognizes the 45 kDa procaspase-1 as well as the 20 kDa cleaved caspase-1.

Application

This Anti-Caspase 1 Antibody is validated for use in IF, IP, WB for the detection of Caspase 1.
Western blot: 1-4 μg/mL

Immunoprecipitation: 4-8 μg/mL

Immunofluorescence: 10-20 μg/mL

Optimal working dilutions must be determined by end user.

Physical form

Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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