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AB2255

Sigma-Aldrich

Anti-GABA B Receptor R2 Antibody

serum, from guinea pig

Synonym(s):

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

guinea pig

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rhesus macaque, rat

species reactivity (predicted by homology)

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_113990

UniProt accession no.

O88871

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GABBR2(9568)

General description

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Specificity

This antibody recognizes the C-terminus of rat GABA-B-R2.

Immunogen

Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.

Application

Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB.

Quality

Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.

Target description

Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present.

Linkage

Replaces: AB5394

Analysis Note

Control
Purkinje cells in rat mid-brain region

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Yupeng Miao et al.
Nature communications, 12(1), 4518-4518 (2021-07-28)
Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017
Francisco Ciruela et al.
The European journal of neuroscience, 32(8), 1265-1277 (2010-09-18)
The stimulation of inhibitory neurotransmitter receptors, such as γ-aminobutyric acid type B (GABA(B) ) receptors, activates G protein-gated inwardly-rectifying K(+) (GIRK) channels, which influence membrane excitability. There is now evidence suggesting that G protein-coupled receptors and G protein-gated inwardly-rectifying K(+)
Chuanyin Hu et al.
Molecular medicine reports, 15(2), 975-980 (2016-12-31)
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established

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