AB5308
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, CT
serum, Chemicon®
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
hamster, human, mouse, monkey
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PSEN1(5663)
Specificity
Presenilin-1, Loop.
Immunogen
Epitope: loop, a.a. 275-367, C-terminus
Human Presenilin-1 (amino acids 275-367) fused to C-terminus of maltose binding protein.
Application
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, C-terminus is an antibody against Presenilin-1 for use in IP, WB & IC.
Immunocytochemistry: Cos7, SY5Y cell lines.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
Western blot: 1:500-1:3000
Immunoprecipitation.
Optimal working dilutions must be determined by end user.
Physical form
Rabbit serum. Liquid in PBS with 0.01% sodium azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
Pricing
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.
Chen, Y; Bodles, AM; McPhie, DL; Neve, RL; Mrak, RE; Griffin, WS
Mol. Neurodegener. null
Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat.
P Kasa, H Papp, M Pakaski
Brain Research null
Anna Bergman et al.
The Journal of biological chemistry, 279(44), 45564-45572 (2004-08-24)
The gamma-secretase complex catalyzes the cleavage of the amyloid precursor protein in its transmembrane domain resulting in the formation of the amyloid beta-peptide and the cytoplasmic APP intracellular domain. The active gamma-secretase complex is composed of at least four subunits:
Arnaldo Parra-Damas et al.
Scientific reports, 7(1), 18004-18004 (2017-12-23)
Gene expression mediated by the transcription factor cAMP-responsive element-binding protein (CREB) is essential for a wide range of brain processes. The transcriptional coactivartor CREB-regulated transcription coactivator-1 (CRTC1) is required for efficient induction of CREB target genes during neuronal activity. However, the mechanisms regulating induction of specific CREB/CRTC1-dependent
Marcella M Authiat et al.
Neural plasticity, 2022, 3172861-3172861 (2022-03-04)
Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine
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