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ABC851

Sigma-Aldrich

Anti-MACC1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MACC1(346389)

General description

Metastasis-associated in colon cancer protein 1, also known as SH3 domain-containing protein 7a5, and encoded by the gene name MACC1, is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway. This pathway is involved in cellular growth, epithelialmesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.

Immunogen

Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human MACC1.

Application

Anti-MACC1 Antibody is an antibody against MACC1 for use in western blotting, IHC & immunofluorescence.
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected MACC1 in human liver tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MACC1 in human liver cells.
Research Category
Apoptosis & Cancer

Quality

Evaluated by Western Blotting in Mouse liver tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected MACC1 in Mouse liver tissue lysate.

Target description

~93 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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