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ABE800

Sigma-Aldrich

Anti-SIRT4 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

UniProt accession no.

Q9Y6E7

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SIRT4(23409)

General description

NAD-dependent protein deacetylase sirtuin-4 (SIRT4) is also called NAD-dependent ADP-ribosyltransferase sirtuin-4 and SIR2-like protein 4 (SIR2L4). SIRT4 catalyzes the transfer of ADP-ribosyl groups onto target proteins, and has been shown to inhibit GLUD1 enzyme activity, down-regulate insulin secretion and is involved in chromatin silencing. SIRT4 is believed to be a transcriptional regulator in embyonic stem cell and hematopoietic stem cells. SIRT4 is widely expressed and has been detected in vascular smooth muscle and striated muscle, and pancreatic (islets of Langerhans) insulin-producing beta-cells.

Specificity

This antibody is predicted to not cross-react with other Sirtuin family members.

Immunogen

Epitope: N-terminus
KLH-conjugated synthetic peptide corresponding to the N-terminus of human SIRT4.

Application

Anti-SIRT4 Antibody detects level of SIRT4 & has been published & validated for use in SIRT4.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SIRT4 in human liver tissue lysate.

Target description

~38 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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