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ABS796

Sigma-Aldrich

Anti-phospho-HER4 Antibody (Tyr1162)

from rabbit, purified by affinity chromatography

Synonym(s):

ERBB4, HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, s80HER4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

Q15303

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr1162)

Gene Information

human ... ERBB4(2066)

General description

Receptor tyrosine-protein kinase erbB-4, also known as, Proto-oncogene-like protein c-ErbB-4 (4ICD or E4ICD), and encoded by the gene names Erbb4 or Tyro-2, plays an essential role as cell surface receptor for neuregulins. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. ERBB4 is preferentially expressed in the developing nervous system. It exhibits distinct and highly regionalized patterns of expression in the adult brain, where it is mainly found in the reticular nucleus of the thalamus.

Immunogen

Epitope: Phosphorylated Tyr1162
KLH-conjugated synthetic peptide corresponding to human PGK1 phosphorylated at Tyr1162.

Application

Detect HER4 using this rabbit polyclonal Anti-phospho-HER4 Antibody, Cat. No. ABS796, validated for use in Western Blotting, Immunohistochemistry, and Immunocytochemistry.
Immunohistochemistry Analysis (IHC): A 1:10-50 dilution from a representative lot detected HER4 in human cancer tissue.

Immunocytochemistry Analysis (ICC): A 1:10-50 dilution from a representative lot detected HER4 in MCF-7 cells.



Quality

Evaluated by Western Blotting in untreated and EGF treated A431 cell lysates.

Western Blotting Analysis (WB): A 1:1000 dilution of this antibody detected HER4 in untreated and EGF treated A431 cell lysates.

Target description

~160 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Purified rabbit polyclonal in buffer containing PBS with 0.09% (W/V) sodium azide.

Other Notes

Concentration: Please refer to lot specific datasheet.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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