ABT280
Anti-Periostin (Pan) Antibody
0.5 mg/mL, from rabbit
Synonym(s):
Periostin, PN, Osteoblast-specific factor 2, OSF-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
concentration
0.5 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Postn(50706)
General description
Periostin, also known as PN, or Osteoblast-specific factor 2 (OSF-2), and encoded by the gene POSTN/OSF2, is a secreted extracellular matrix protein that appears to be involved in inducing cell attachment and spreading as well as cell adhesion. In bone, Periostin enhances mineralization and assists in the incorporation of BMP1 protein into the fibronectin extracellular matrix of connective tissues. Periostin is preferentially expressed in periosteum and periodontal ligaments but can also be found expressed in developing heart and other tissues. Periostin is also over expressed in many cancers where is contributes to a growth-supportive role for such cancers and also aids in chemoresistance for cancers cells through the activation of the PI3K/Akt/surviving pathway.
Specificity
This antibody detects all splice variants of Periostin.
Immunogen
Linear peptide from the fasciclin 1 domain of mouse periostin.
Application
Anti-Periostin (Pan) Antibody is an antibody against Periostin (Pan) for use in western blotting & IHC.
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
Western Blotting Analysis: A representative lot detected Periostin (Pan) in mouse lung extract.
Immunohistochemistry Analysis: A representative lot detected Periostin (Pan) in certain reported tissues (Kruzynska-Frejtag, A., et al. (2004). Dev Dyn. 229(4):857-868.; Butcher, J. T., et al. (2007). Dev Biol. 302(1):256-266.; Norris, R. A., et al. (2007). J Cell Biochem. 101(3):695-711.; Inai, K., et al. (2008). Dev Biol. 315(2):383-396.; Norris, R. A., et al. (2008). Dev Biol. 316(2):200-213.).
Immunohistochemistry Analysis: A representative lot detected Periostin (Pan) in certain reported tissues (Kruzynska-Frejtag, A., et al. (2004). Dev Dyn. 229(4):857-868.; Butcher, J. T., et al. (2007). Dev Biol. 302(1):256-266.; Norris, R. A., et al. (2007). J Cell Biochem. 101(3):695-711.; Inai, K., et al. (2008). Dev Biol. 315(2):383-396.; Norris, R. A., et al. (2008). Dev Biol. 316(2):200-213.).
Quality
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Periostin (Pan) in 10 µg of mouse lung tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Periostin (Pan) in 10 µg of mouse lung tissue lysate.
Target description
~75-85 kDa observed. Uniprot describes five isoforms at 93 kDa, 90 kDa, 90 kDa, 87 Kda, and 87 kDa However, this protein has been observed between 75-85 kDa
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing PBS.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Agnieszka Kruzynska-Frejtag et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 229(4), 857-868 (2004-03-26)
Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment, and spreading. The protein was renamed "periostin" because of its expression in the
Jonathan T Butcher et al.
Developmental biology, 302(1), 256-266 (2006-10-31)
Recent evidence suggests that extracellular matrix components may play a signaling role in embryonic valve development. We have previously identified the spatiotemporal expression patterns of periostin in developing valves, but its function during this process is largely unknown. To evaluate
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.
Norris, Russell A, et al.
Journal of Cellular Biochemistry, 101, 695-711 (2007)
Russell A Norris et al.
Developmental biology, 316(2), 200-213 (2008-03-04)
Cardiac valve leaflets develop from rudimentary structures termed endocardial cushions. These pre-valve tissues arise from a complex interplay of signals between the myocardium and endocardium whereby secreted cues induce the endothelial cells to transform into migratory mesenchyme through an endothelial
N Sakagami et al.
Journal of dental research, 97(11), 1260-1267 (2018-05-11)
Craniofacial development requires a set of patterning codes that define the identities of postmigratory mesenchymal cells in a region-specific manner, in which locally expressed morphogens, including fibroblast growth factors (FGFs) and bone morphogenetic proteins (BMPs), provide instructive cues. Msx2, a
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