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FCMAB178P

Sigma-Aldrich

Milli-Mark® Anti-CD11B-PE Antibody, clone 2LPM19c

clone 2LPM19c, Milli-Mark®, from mouse

Synonym(s):

Integrin alpha-M, Cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11 antigen-like family member B

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.44

biological source

mouse

Quality Level

100

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2LPM19c, monoclonal

species reactivity

human

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NP_000623.2

UniProt accession no.

P11215

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGAM(3684)

Related Categories

General description

CD11b is the 165 kDa α-chain of the Mac-1 complex. The molecule, also called CR3, functions as a cell surface receptor for the C3bi complement fragment. There is evidence that CD11b can bind fibrinogen in addition to C3bi (Wright,1988). Two binding sites have now been reported, one recognizing lipopolysaccharide, and the other protein ligands containing the arg-gly-asp sequence (Wright, 1989). Binding of the coagulation factor X has also been suggested as an additional receptor role of CD11b (Altieri,1988). This protein belings to a family of related heterodimeric proteins designated CD11 in the classification system for human leucocyte differentiation antigens, which shares a common β-chain with a MW of 95 kDa (CD18). Besides the C3bi receptor, this protein family contains two other members, leucocyte function associated-1 (LFA-1, C11a) antigen and p150,95 protein (CD11c) (Sanchez-Madrid,1983).

Specificity

Antibody recognizes Human CD11b antigen.

Immunogen

Purified iC3b receptor.

Application

Milli-Mark Anti-CD11B-PE Antibody, clone 2LPM19c detects level of CD11B & has been published & validated for use in FC.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Quality

Evaluated by flow cytometry using human PBMCs

Target description

165 kDa (Wright, 1988)

Physical form

Protein A purified
Purified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Storage and Stability

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.

Analysis Note

Control
PBMCs

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hee Doo Lee et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(7), 3084-3095 (2012-04-17)
A disintegrin and metalloproteinase 15 (ADAM15), the only ADAM protein containing an Arg-Gly-Asp (RGD) motif in its disintegrin-like domain, is a widely expressed membrane protein that is involved in tumor progression and suppression. However, the underlying mechanism of ADAM15-mediated tumor
Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia.
Son, HJ; Kim, JY; Hahn, Y; Seo, SB
Molecular and cellular biology null

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