GF308
NT-3 Protein, Human Recombinant Animal Free
Recombinant animal free human NT-3 is manufactured using all non-animal reagents.
Synonym(s):
NT3, Neurotrophin 3, HDNF, Nerve growth factor 2, Neurotrophic factor
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.77
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General description
Neurotrophin3 (NT3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT3, and NT4/5. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues).Human and Mouse NT-3 sequences are identical.
Product Source: E. coli
Specificity
Cross Reactivty
None
None
Application
Recombinant animal free human NT-3 is manufactured using all non-animal reagents.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Quality
Bioactivity assay: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.
Physical form
Product is filtered through a 0.2 micron filter before lyophilization. Product is presented in .
Recombinant animal free human NT-3 is manufactured using all non-animal reagents
Storage and Stability
Store at -20°C for up to 6 months from date of receipt.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Samuel Lawn et al.
The Journal of biological chemistry, 290(6), 3814-3824 (2014-12-30)
Neurotrophins and their receptors are frequently expressed in malignant gliomas, yet their functions are largely unknown. Previously, we have shown that p75 neurotrophin receptor is required for glioma invasion and proliferation. However, the role of Trk receptors has not been
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