MAB1383
Anti-Integrin α4 Antibody, clone HP2/1
clone HP2/1, Chemicon®, from mouse
Synonym(s):
CD49d
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HP2/1, monoclonal
species reactivity
human, bovine, rat
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... ITGA4(3676)
rat ... Itga4(311144)
Related Categories
Specificity
Recognizes the 80kDa alpha chain of VLA-4. Reacts with monocytes, T cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1.
Immunogen
JM leukemia line
Application
Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone HP2/1 validated for use in FC, IP, IH.
Flow cytometry: 1μg/5 X 10E5 cells
Immunohistology on frozen tissue sections
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunohistology on frozen tissue sections
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Linkage
Replaces: 04-1131
Physical form
Format: Purified
Purified immunoglobulin - Ig fraction. Liquid in Phosphate Buffered Saline, pH 7.4 with 0.1% Sodium Azide.
Storage and Stability
Store at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.
Weller, P F, et al.
Proceedings of the National Academy of Sciences of the USA, 88, 7430-7433 (1991)
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Hidenobu Kanda, Rebecca Newton, Russell Klein, Yuka Morita, Michael D Gunn, Steven D Rosen
Nature Immunology null
VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines.
Mattila, P, et al.
International Journal of Cancer. Journal International Du Cancer, 52, 918-923 (1992)
VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization.
Sanchez-Madrid, F, et al.
European Journal of Immunology, 16, 1343-1349 (1986)
Jinah Park et al.
Oncogene, 23(19), 3474-3480 (2004-03-03)
Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their
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