MAB2076Z
Anti-Integrin β6 Antibody, clone CSβ6, azide free
clone CSbeta6, Chemicon®, from mouse
Synonym(s):
MAB2076
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
CSbeta6, monoclonal
species reactivity
human, monkey, rat, rabbit
should not react with
mouse
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGB6(3694)
mouse ... Itgb6(16420)
rat ... Itgb6(311061)
rhesus monkey ... Itgb6(700454)
Related Categories
Specificity
Monoclonal antibody MAB2076Z, raised by immunizing beta6 knockout mice with recombinant secreted human alphavbeta6, is useful for flow cytometry and immunoprecipitation in all species tested, including mouse. It also works well for immunohistochemistry of acetone-fixed tissues in several species, including rat, rabbit, monkey, and human. The antibody does not work well for immunohistochemistry of mouse tissue. This antibody does not recognize the aV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only.
Immunogen
beta 6 knockout mice have been immunized with recombinant secreted human alpaVbeta6.
Application
Anti-Integrin β6 Antibody, clone CSβ6, azide free detects level of Integrin β6 & has been published & validated for use in FC, IP, IC, IH.
Immunohistochemistry (acetone fixation): Effective for Rabbit, rat, monkey, and human. Not effective for mouse tissue.
Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested).
Flow cytometry: Effective for all species tested, including rabbit, rat, monkey, human, and mouse.
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested).
Flow cytometry: Effective for all species tested, including rabbit, rat, monkey, human, and mouse.
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Physical form
Format: Purified
Sterile-filtered liquid at 1 mg/mL in PBS, containing no preservatives.
Storage and Stability
Maintain at 2-8°C.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A continuous bovine kidney cell line constitutively expressing bovine ?v?6 integrin has increased susceptibility to foot-and-mouth disease virus.
LaRocco, M; Krug, PW; Kramer, E; Ahmed, Z; Pacheco, JM; Duque, H; Baxt, B; Rodriguez, LL
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A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density.
Gray, BP; McGuire, MJ; Brown, KC
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Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.
Williams, CH; Kajander, T; Hyypia, T; Jackson, T; Sheppard, D; Stanway, G
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Aliakbar Taherian et al.
BMC cancer, 11, 293-293 (2011-07-15)
Integrins are used as prognostic indicators in breast cancer. Following engagement with extracellular matrix proteins, their signaling influences numerous cellular processes including migration, proliferation, and death. Integrin signaling varies between cell types through differential expression of integrin subunits, and changes
Dana L Nettles et al.
Journal of anatomy, 204(6), 515-520 (2004-06-17)
In this study, we investigated the profile of integrin expression in human and porcine intervertebral disc tissue. Differences in extracellular matrix composition between anulus fibrosus (AF) and nucleus pulposus (NP) regions of the disc, as well as differences in cellular
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