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MAB4132

Sigma-Aldrich

Anti-BRCA1 Antibody, clone BR64

clone BR64, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

BR64, monoclonal

species reactivity

human, mouse

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_007294.2
NM_007295.2
NM_007296.2
NM_007297.2
NM_007298.2
NM_007299.2
NM_007300.2
NM_007302.2
NM_007303.2
NM_007304.2
NM_007305.2

UniProt accession no.

P38398

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... BRCA1(672)

Related Categories

Specificity

The breast cancer susceptibility gene, BRCA1*, is located on chromosome 17 (at q21), and is mutated in the majority of heritable breast cancers. The mutations within the coding region occur throughout the gene with little apparent clustering. The majority of BRCA1 mutations result in shortened BRCA1 gene products, creating a need for an amino-terminal marker. Antibody MAB4132 recognizes both the full-length and mutated (shortened) forms of BRCA1 in breast cancer cell lines. It also recognizes over-expressed protein in transiently transfected Cos cells. A single cross-reacting protein of approximately 27 kDa is also seen upon immunoprecipitation. No other cross-reacting proteins are detected.

BRAC1 is 220kDa.

*BRCA1 is covered under U.S. patents 5,747,282, 5,753,441 and 6,162,897.

Immunogen

Purified polypeptide representing a 100-amino acid segment of the amino terminus of the BRCA1 gene product.

Application

Anti-BRCA1 Antibody, clone BR64 is a high quality Mouse Monoclonal Antibody for the detection of BRCA1 & has been validated in IP & WB.
Immunoprecipitation

Western blot

Optimal working dilutions must be determined by end user.

Quality

Tested

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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flash_point_f

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flash_point_c

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nuclear redistribution of BRCA1 during viral infection
Maul, G. et al.
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research, 9, 743-755 (1998)
Pragati Katiyar et al.
Molecular endocrinology (Baltimore, Md.), 23(8), 1135-1146 (2009-04-25)
Previously, we reported that BRCA1 inhibits progesterone receptor (PR) activity and blocks progesterone-stimulated gene expression and cell proliferation. In the present manuscript, we studied the mechanism of BRCA1 inhibition of PR activity, using c-Myc as a model progesterone-regulated promoter. Here

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