MAB5258A4
Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor™ 488 Conjugate
clone SY38, from mouse, ALEXA FLUOR™ 488
Synonym(s):
Synaptophysin, Major synaptic vesicle protein p38
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
purified antibody
antibody product type
primary antibodies
clone
SY38, monoclonal
species reactivity
mouse, human
species reactivity (predicted by homology)
bovine (immunogen homology)
technique(s)
immunohistochemistry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SYP(6855)
General description
Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
Specificity
This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells.
Immunogen
Vesicular fraction of bovine brain
Application
Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate detects level of Synaptophysin & has been published & validated for use in IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuronal & Glial Markers
Neuronal & Glial Markers
Quality
Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.
Target description
The unconjugated parent antibody (Cat. No. MAB5258) has an observed molecular weight at ~38 kDa
Physical form
Protein G purified
Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor™ 488 in buffer containing 15 mg/ml BSA with 0.1% sodium azide.
Storage and Stability
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Analysis Note
Control
Adult mouse brain tissue
Adult mouse brain tissue
Other Notes
Uncongugated antibody (MAB5258) is shown to work on Rat.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Zhexing Wen et al.
Nature, 515(7527), 414-418 (2014-08-19)
Dysregulated neurodevelopment with altered structural and functional connectivity is believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the major hypothesis for the biological basis of schizophrenia. Although this hypothesis has gained indirect support from human post-mortem
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