MAB5620
Anti-Norepinephrine Transporter Antibody
ascites fluid, Chemicon®
Synonym(s):
NET
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
ascites fluid
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, monkey
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SLC6A2(6530) , SLC6A5(9152)
Specificity
Norepinephrine Transporter, human and non-human primate.
Immunogen
Synthetic peptide from human norepinephrine Transporter.
Application
Detect Norepinephrine Transporter using this Anti-Norepinephrine Transporter Antibody validated for use in IH.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Deborah C Mash et al.
Journal of neuroscience methods, 143(1), 79-85 (2005-03-15)
The norepinephrine transporter (NET) is a membrane protein responsible for transporting extracellular norepinephrine. The cocaine and tricyclic antidepressant-sensitive NET belongs to a family of sodium and chloride coupled transporters that include the monoamines dopamine and serotonin and the amino acids
Maureen K Hahn et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(11), 4470-4478 (2003-06-14)
The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrenergic neurotransmission. Recently, our laboratory reported a polymorphism in the human NET (hNET) gene A457P in an individual with the
Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.
Apparsundaram, S, et al.
Journal of Pharmacology and Experimental Therapeutics, 299, 666-677 (2001)
Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress
Mao, Weike, et al
American Journal of Physiology. Heart and Circulatory Physiology, 288, H2381-H2389 (2005)
Katherine L Holton et al.
Nature neuroscience, 8(7), 881-888 (2005-06-01)
Neurotransmitter transporters are critical for synaptic neurotransmitter inactivation. Transporter inhibitors markedly increase the duration and magnitude of synaptic transmission, underscoring the importance of transporter activity in neurotransmission. Recent studies indicate that membrane trafficking dynamically governs neuronal transporter cell-surface presentation in
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