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MABF158C

Sigma-Aldrich

Anti-CD152 (CTLA-4) (mouse), PE-Cy7, clone UC10-4F10-11 Antibody

clone UC10-4F10-11, from hamster(Armenian), PE-Cy7

Synonym(s):

Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), CD152, CD152 (CTLA-4)

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.44

biological source

hamster (Armenian)

Quality Level

100

conjugate

PE-Cy7

antibody form

purified antibody

antibody product type

primary antibodies

clone

UC10-4F10-11, monoclonal

species reactivity

mouse

packaging

antibody small pack of 25 μg

technique(s)

flow cytometry: suitable

isotype

IgG

UniProt accession no.

P09793

target post-translational modification

unmodified

Gene Information

mouse ... Ctla4(12477)

Related Categories

General description

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Application

This armenian hamster monoclonal Anti-CD152 (CTLA-4) Antibody (mouse), PE-Cy7, clone UC10-4F10-11, Cat. No. MABF1586 is validated for use in Flow Cytometry, for the detection of CD152 (CTLA-4).

Quality

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Other Notes

Concentration: Please refer to lot specific datasheet.

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