MABF41
Anti-Interleukin-6 (IL-6) Antibody, clone 1G3
clone AB42_51.38C8.1G3, from mouse
Synonym(s):
interleukin 6 (interferon, beta 2), IFN-beta-2, B-cell stimulatory factor 2, interleukin-6, Interferon beta-2, B cell stimulatory factor-2, Hybridoma growth factor, B-cell differentiation factor, CTL differentiation factor, interleukin BSF-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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General description
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
Immunogen
Human IL-6 fused to the soluble domain of the IL-6R.
Application
Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
Quality
Evaluated by Western Blot with human IL-6 recombinant protein.
Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.
Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.
Target description
~21 kDa observed
Linkage
Replaces: 04-1095
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human IL-6 recombinant protein
Human IL-6 recombinant protein
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Xiaoli Zhou et al.
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