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MABT189

Sigma-Aldrich

Anti-Delta3 Antibody, clone 1E7.2

clone 1E7.2, from mouse

Synonym(s):

Delta-like protein 3, Drosophila Delta homolog 3, Delta3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1E7.2, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_058637

UniProt accession no.

Q9NYJ7

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DLL3(10683)

Related Categories

General description

DLL3, also known as Delta like ligand 3, is a transmembrane Delta-like protein principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation to inhibit primary neurogenesis. DLL3 is one of five DSL proteins that bind to the Notch receptor. Notch signaling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands family members are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in the DLL3 gene causes autosomal recessive spondylocostal dysostosis.

Immunogen

Linear peptide corresponding to human Delta3.

Application

Flow Cytometry Analysis: 0.1 µg from a representative lot detected Delta3 in HEK293 cells.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
This Anti-Delta3 Antibody, clone 1E7.2 is validated for use in WB, FC for the detection of Delta3.

Quality

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Delta3 on 10 µg of human liver tissue lysate.

Target description

~65 kDa observed

Physical form

Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human liver tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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