MABT64
Anti-Nectin-4/PVRL4 Antibody, clone N4.61
clone N4.61.2, from mouse
Synonym(s):
poliovirus receptor-related 4, Ig superfamily receptor LNIR, nectin 4, poliovirus receptor-related protein 4, nectin-4, Nectin-4
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N4.61.2, monoclonal
species reactivity
human
technique(s)
ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PVRL4(81607)
Related Categories
General description
Nectin-4 is also known as poliovirus receptor-related protein 4 (PRR4 or PVRL4). Nectins are known for being the receptors for the herpes simplex virus. Nectin-4 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectin-4 is connected with the actin cytoskeleton through afadin inside the cell. Nectin-4 is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-4 seems to adhere primarily to cells expressing nectin-1 and vice versa.
Immunogen
Recombinant protein corresponding to human Nectin-4.
Application
Anti-Nectin-4/PVRL4 Antibody, clone N4.61 is an antibody against Nectin-4/PVRL4 for use in IH, ELISA & IP.
ELISA Anaysis: A previous lot was used by an independent laboratory in ELISA (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).
Immunoprecipitation Anaysis: A previous lot was used by an independent laboratory in IP (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).
Immunoprecipitation Anaysis: A previous lot was used by an independent laboratory in IP (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
Quality
Evaluated by Immunohistochemistry in ductal carcinoma tissue.
Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected Nectin-4/PVRL4 in ductal carcinoma tissue.
Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected Nectin-4/PVRL4 in ductal carcinoma tissue.
Target description
55 kDa calculated
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Ductal carcinoma tissue
Ductal carcinoma tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.
Reymond, N; Fabre, S; Lecocq, E; Adelaide, J; Dubreuil, P; Lopez, M
The Journal of Biological Chemistry null
Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17.
Fabre-Lafay, S; Garrido-Urbani, S; Reymond, N; Goncalves, A; Dubreuil, P; Lopez, M
The Journal of Biological Chemistry null
Kristin L M Boylan et al.
Oncotarget, 8(6), 9717-9738 (2016-12-31)
The cell adhesion molecule Nectin-4 is overexpressed in epithelial cancers, including ovarian cancer. The objective of this study was to determine the biological significance of Nectin-4 in the adhesion, aggregation, migration, and proliferation of ovarian cancer cells. Nectin-4 and its
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