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MILLIPLEX® Rat/Mouse Neuropeptide Magnetic Bead Panel - Neuroscience Multiplex Assay

The analytes available for this multiplex kit are: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Quality Level

200

species reactivity

mouse, rat

manufacturer/tradename

Milliplex®

assay range

accuracy: 107-135%
(Rat)
standard curve range: 14-100,000 pg/mL
(Oxytocin)
standard curve range: 27-20,000 pg/mL
(Neurotensin)
standard curve range: 3-2,000 pg/mL
(Substance P)
standard curve range: 41-30,000 pg/mL
(α-MSH)
standard curve range: 69-50,000 pg/mL
(β-Endorphine)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

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General description

The MILLIPLEX® Rat/Mouse Neuropeptide Bead Panel, containing 5 biomarkers. This kit may be used for the analysis of all or any combination of the above analytes in tissue/cell lysate/culture supernatant samples and cerebrospinal fluid (CSF). Serum or plasma samples may also be used, and will need to be extracted, however we do not recommend using the panel for serum and plasma Substance P. The kit contains enough material to analyze 38 samples in duplicate, including the standard curve and two quality controls.

An important note about this panel is that the samples may be extracted using either the acetonitrile precipitation technique or the Waters 96-well HLB extraction plate. Please refer to the protocol for more information on both methods. The necessary components to perform the extractions are not included with the kit.

The central nervous system is a complex environment consisting of billions of neurons as well as glial support cells. These neurons use many different chemical signals to communicate information, including neurotransmitters, cannabinoids, peptides, and gases such as nitric oxide. Neuropeptides are secreted primarily from the central and peripheral nervous systems, exerting a broad spectrum of biological functions that includes the regulation of metabolism, reproduction, and immunity.

Panel Type: Neuroscience

Application

  • Analytes: α-MSH, β-Endorphin, Neurotensin, Oxytocin, Substance P.
  • Recommended Sample type: serum, plasma, CSF, and tissue culture
  • Recommended Sample dilution: This assay requires 50 μL extracted serum or plasma sample per well or 50 μL neat CSF or culture media per well
  • Assay Run Time: Overnight
  • NOTE: this is a competitive assay.

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Willem J van den Brink et al.
The AAPS journal, 19(1), 274-285 (2016-10-28)
To reveal unknown and potentially important mechanisms of drug action, multi-biomarker discovery approaches are increasingly used. Time-course relationships between drug action and multi-biomarker profiles, however, are typically missing, while such relationships will provide increased insight in the underlying body processes.
Jen-Yin Goh et al.
Brain, behavior, and immunity, 89, 100-117 (2020-06-03)
Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents, to understand disease mechanisms and evaluate novel treatments, particularly for poorly-managed negative and
Jorge Moreno-Fernández et al.
Nutrients, 11(10) (2019-10-09)
Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide. Iron plays critical roles in nervous system development and cognition. Despite the known detrimental consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating
Weiling Yin et al.
Neurobiology of aging, 83, 1-10 (2019-10-05)
The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing

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