YUMMER1G.1F Mouse Cell Line

The great promise of immune-based therapies in cancer and recent progress in successful application of these approaches has brought to the fore the necessity of immune-competent models to evaluate immune system responses to cancer cells. Melanomas exhibit relatively high somatic mutation burden, and these mutations may act as neoantigens that generate anti-tumor immune responses. The development of immunocompetent cell models is critical to the advancement of cancer immunotherapy and understanding of immunity, although few tractable model systems are available.


References
1. Pigment Cell Melanoma Res 2016, 29(5): 590-597.
2. Nat Genet 2009, 41(5): 544-552.
3. Pigment Cell Melanoma Res 2017, 30(4): 428-435.
4. Ramseier JY, Charos A, Park K, Damsky W, Bosenberg MW (2019). Cancer Res 79(13 Suppl) Abstract #4622.

The characteristics of the YUMMER1.G1F cell line make it a valuable model for investigating sex-related differences in immune checkpoint inhibition and mechanisms of anti-tumor responses.

The cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.

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