HPDE6c7 Human Pancreatic Duct Epithelial Cell Line

Pancreatic cancer is the fourth commonest cause of cancer death in North America and has one of the worst prognoses. Greater than 90% of these tumors arise from the pancreatic duct epithelium.1 Even when the primary tumor is small and localized, the prognosis remains poor and chemotherapy or radiotherapy has demonstrated limited effectiveness.2 The availability of dynamic models remains crucial to the study and understanding of the biological significance of the genetic changes underlying pancreatic cancer, especially in the context of pancreatic duct epithelial cell carcinogenesis.
The immortalized HPDE6c7 cell line demonstrates a near normal genotype and phenotype of pancreatic duct epithelial cells.3 HPDE6c7 cells retain normal Ki-ras, p53, C-myc, and p16INK4A genotypes but lack the p53 functional pathway.3 The HPDE6c7 cell line is useful for studies on the molecular basis of pancreatic duct cell carcinogenesis and islet cell differentiation. HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

Source
HPDE6c7 cells originated from normal human pancreatic duct of a 63-year-old female, having been genotypically altered by infection with retrovirus vector expressing E6E7 genes of human papilloma virus (HPV)-16.3


References
1. Am J Pathol 1996, 148(6): 1763-1770.
2. Am J Pathol 1998, 153(1): 263-269.
3. Am J Pathol 2000, 157(5): 1623-1631.

HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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