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15527

Sigma-Aldrich

Glycine

meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
Beilstein/REAXYS Number:
635782
EC Number:
200-272-2
MDL number:
MFCD00008131
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57647473
NACRES:
NA.21

Quality Level

200

assay

99-101% (based on anhydrous substance)

form

crystalline powder

quality

meets analytical specification of Ph. Eur., BP, USP

technique(s)

IR spectroscopy: suitable

impurities

hydrolyzable substances, complies
 organic volatile impurities, complies (GC)
 residual solvents, complies
≤0.001% heavy metals (as Pb)
≤1.0% ninhydrin-positive substances

ign. residue

≤0.1% (as SO4)

loss

≤0.2% loss on drying, 105 °C, 2 h

color

white

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H2O: soluble 25 gm in 100 ml at 25 degrees c
H2O: soluble 39.1 gm in 100 ml at 50 degrees c
alcohol: soluble 0.06 gm in 100 gm (Absolute)
pyridine: soluble 164 parts
alcohol: very slightly soluble
diethyl ether: very slightly soluble

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4
in accordance for identity (IR)

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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Application

Glycine was used for preparing platelets from whole-blood samples and study the stimulation of cytokine expression in leukocytes. It was used for biochemical and tolerance tests.

Biochem/physiol Actions

Glycine has a pivotal role in lowering the plasma lipid levels in diabetic and obese patients by activating the CNS. During brain hypoxia glycine can stabilize the energetics disturbances in brain mitochondria. It also increases the in vitro development of porcine blastocysts when used along with glucose.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1004
STBK8220
STBK6054
STBK2156
STBJ6094

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Glycine suitable for electrophoresis, ≥99%

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SAFC

1.03669

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Glycine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

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Glycine

Calcium chloride dihydrate EMPROVE® EXPERT, Ph. Eur., BP, JP, USP

SAFC

1.37101

Calcium chloride dihydrate

Jessica T Y Yue et al.
Circulation research, 110(10), 1345-1354 (2012-04-05)
Dysregulation of hepatic triglyceride (TG)-rich very low-density lipoproteins (VLDL-TG) in obesity and type 2 diabetes contributes to the dyslipidemia that leads to cardiovascular morbidity. The central nervous system (CNS), particularly the hypothalamus, regulates hepatic lipid metabolism. Although the underlying neurocircuitry
Tomomi Mito et al.
Reproduction, fertility, and development, 24(3), 443-450 (2012-03-10)
In the present study, the effects of glucose and/or glycine on the in vitro development of Day 5 (Day 0=IVF) porcine blastocysts were determined. The addition of 2.5-10 mM glucose to the chemically defined culture medium porcine zygote medium (PZM)-5
A A Selin et al.
Bulletin of experimental biology and medicine, 153(1), 44-47 (2012-07-19)
Glycine stabilizes energetics of brain mitochondria under conditions of brain hypoxia in vivo modeled by ligation of the common carotid artery in rats. Hypoxia reduced respiratory control in brain cortex mitochondria from 7.7 ± 0.5 to 4.5 ± 0.3. Preliminary
F J Neumann et al.
Circulation, 95(10), 2387-2394 (1997-05-20)
Activated platelets tether and activate myeloid leukocytes. To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI. We obtained peripheral
F Megraud et al.
Journal of clinical microbiology, 22(6), 1007-1010 (1985-12-01)
"Campylobacter pyloridis" has been recently described as a gastritis-associated bacterium. We studied 20 strains. The bacteria had most of the characteristics of Campylobacter spp. strains. They were hippurate negative and tolerant to triphenyl tetrazolium chloride (at 0.4 and 1 mg/ml).
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