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Supelco

Cellulose acetate phthalate

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About This Item

Empirical Formula (Hill Notation):
C116H116O64
CAS Number:
9004-38-0
Molecular Weight:
2534.12
MDL number:
MFCD00072769
UNSPSC Code:
12000000
NACRES:
SB.52

form

powder

Quality Level

200

technique(s)

LPLC: suitable

matrix

acetylated cellulose

matrix active group

phthalate

capacity

1.0 meq/mL

separation technique

reversed phase

InChI

1S/C32H34O19/c1-13(33)45-11-19-21(35)25(49-29(42)17-9-5-3-7-15(17)27(38)39)23(37)32(48-19)51-24-20(12-46-14(2)34)47-31(44)26(22(24)36)50-30(43)18-10-6-4-8-16(18)28(40)41/h3-10,19-26,31-32,35-37,44H,11-12H2,1-2H3,(H,38,39)(H,40,41)/t19-,20-,21-,22+,23-,24-,25+,26-,31-,32+/m1/s1

InChI key

DMNFZTKVDDFCQE-WJXNTJCASA-N

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General description

Cellulose acetate phthalate (CAP) is a microbicide which inactivates sexually transmitted disease (STD) pathogens like HIV-1. CAP has been used for enteric film coating of tablets and capsules.

Application

CAP is used as a stabiling agent in the preparation of Pseudolatex.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD4766
BCBW5667
BCBN9248V
BCBK8299V
BCBK3366V

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Sigma-Aldrich

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Sigma-Aldrich

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Hypromellose phthalate European Pharmacopoeia (EP) Reference Standard

Y0000915

Hypromellose phthalate

D Quintanar-Guerrero et al.
International journal of pharmaceutics, 188(2), 155-164 (1999-10-16)
Pseudolatexes were obtained by a new process based on an emulsification-diffusion technique involving partially water-miscible solvents. The preparation method consisted of emulsifying an organic solution of polymer (saturated with water) in an aqueous solution of a stabilizing agent (saturated with
A Robert Neurath et al.
BMC infectious diseases, 3, 27-27 (2003-11-18)
Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules. Micronized CAP, available commercially as "Aquateric" and containing additional ingredients required for micronization, used for tablet coating
A Robert Neurath et al.
BMC infectious diseases, 2, 6-6 (2002-05-02)
Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site
C J Lacey et al.
International journal of STD & AIDS, 21(10), 714-717 (2010-12-09)
We carried out a phase 1 trial of a candidate vaginal microbicide gel against HIV-1 and other sexually transmitted diseases, which contained cellulose acetate 1,2-benzenedicarboxylate (also known as cellulose acetate phthalate) in a glycerol-based vehicle. We had to terminate the
James C DiNunzio et al.
Molecular pharmaceutics, 5(6), 968-980 (2009-05-13)
Amorphous engineered particle compositions of itraconazole (ITZ) and potential concentration enhancing polymers, cellulose acetate phthalate (CAP) and polyvinyl acetate phthalate (PVAP), were produced by ultra-rapid freezing to investigate the effect of these polymers on the bioavailability of ITZ solid dispersions.
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