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Flubendazol

VETRANAL®, analytical standard

Synonym(s):

Flumoxanal, Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

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About This Item

Empirical Formula (Hill Notation):
C16H12FN3O3
CAS Number:
31430-15-6
Molecular Weight:
313.28
EC Number:
250-624-4
MDL number:
MFCD00871999
UNSPSC Code:
41116107
PubChem Substance ID:
329754807
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3

InChI

1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

InChI key

CPEUVMUXAHMANV-UHFFFAOYSA-N

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General description

Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol is an injectable benzimidazole drug; though it is poorly absorbed it is quite effective in the treatment of trycocephalus, ascaris and oxyuriasis in both children and adults.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL® analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD3951
BCBW0774
SZBF099XV
SZBB157XV
SZB9216XV

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Jung-Min Lee et al.
The Korean journal of parasitology, 49(3), 273-275 (2011-11-11)
Praziquantel is the drug of choice for clonorchiasis. Since clonorchiasis is endemic in most river basins, praziquantel has been widely used for 30 years in Korea. A 54-year-old Korean woman suffered from hypersensitive reactions, such as nausea, dyspnea, rash, and
J Boes et al.
Veterinary parasitology, 172(3-4), 269-276 (2010-06-15)
Scientific investigations of production losses in pigs due to roundworms are rarely conducted in commercial farms, despite the fact that this information is needed to decide whether anthelmintic treatment is cost-effective or not. Therefore, the aim of our study was
V Krízová et al.
Journal of veterinary pharmacology and therapeutics, 32(6), 606-612 (2010-05-07)
Flubendazole (FLU) is indicated for control of helminthoses in pig and avian species (monogastric animals) and its corresponding pharmacokinetics are well known. The information on FLU's pharmacokinetic behavior in animal species with forestomach (ruminants) has been limited although the use
S Squires et al.
Veterinary parasitology, 185(2-4), 352-354 (2011-10-26)
The efficacy of a commercially available flubendazole-based product and a commercially available herbal product were compared against three species of helminth parasites of chickens: Ascaridia galli, Heterakis gallinarum and Capillaria spp. A total of 48 naturally infected chickens were used
Hana Bártíková et al.
Parasitology, 139(6), 809-818 (2012-02-09)
The drug-metabolizing enzymes of some helminths can deactivate anthelmintics and therefore partially protect helminths against these drugs' toxic effect. The aim of our study was to assess the activity of the main drug-metabolizing enzymes and evaluate the metabolism of selected
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