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Supelco

Climbazole

PESTANAL®, analytical standard

Synonym(s):

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

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About This Item

Empirical Formula (Hill Notation):
C15H17ClN2O2
CAS Number:
38083-17-9
Molecular Weight:
292.76
Beilstein/REAXYS Number:
618020
EC Number:
253-775-4
MDL number:
MFCD00055505
UNSPSC Code:
41116107
PubChem Substance ID:
329755277
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

mp

96-100 °C

suitability

passes test for identity (NMR)

application(s)

agriculture
environmental

format

neat

SMILES string

CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2

InChI

1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

InChI key

OWEGWHBOCFMBLP-UHFFFAOYSA-N

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General description

Climbazole is an imidazole antifungal agent, which is widely used as an active ingredient in anti-dandruff (AD) shampoos since, it inhibits the microbial growth and improves skin barrier on scalp.

Application

Climbazole may be used as a reference standard in the determination of climbazole in environmental samples and in samples of anti-dandruff shampoo using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH9771
BCCD3471
BCBT4575
SZBC047XV
SZB7176XV

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Sigma-Aldrich

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Sigma-Aldrich

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Ketoconazole

Alex A Pérez-Rivera et al.
Mutation research, 672(1), 27-39 (2008-10-28)
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. A series of genotoxicity studies were performed to support the human safety of this azole antifungal drug. Climbazole was not mutagenic in the
W Wigger-Alberti et al.
Praxis, 90(33), 1346-1349 (2001-09-06)
Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work
A Schmidt
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 44(4), 193-197 (1997-06-01)
Malassezia pachydermatis is a yeast-like, mainly zoophilic fungus, also known as Malassezia canis. It can be isolated in 20-50% from normal ear cerumen specimen from dogs or cats and has an even higher prevalence in non-suppurative otitis externa in animal
Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography--tandem mass spectrometry
Chen F-Z, et al.
Analytical and Bioanalytical Chemistry, 404(10), 3175-3188 (2012)
Ultra-high-performance liquid chromatography?tandem mass spectrometry measurement of climbazole deposition from hair care products onto artificial skin and human scalp.
Chen G, et al.
Journal of Chromatography A, 1317, 155-158 (2013)
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