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Praziquantel

VETRANAL®, analytical standard

Synonym(s):

2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

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About This Item

Empirical Formula (Hill Notation):
C19H24N2O2
CAS Number:
Molecular Weight:
312.41
Beilstein/REAXYS Number:
761557
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

parasites

application(s)

clinical testing

format

neat

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4

InChI

1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2

InChI key

FSVJFNAIGNNGKK-UHFFFAOYSA-N

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General description

Chemical structure: quinolone
Praziquantel (PZQ) is a pyrazino-isoquinoline compound used as a broad-spectrum anthelmintic drug against trematode and cestode infections.

Application

PZQ may be used as a reference standard for the determination for PZQ in:
  • Surface water samples by solid phase extraction (SPE) and ultra-high performance liquid chromatography-quadrupole linear ion trap tandem mass spectrometry (UHPLC-QqLIT-MS) equipped with electrospray ionization (ESI) source.
  • Plants by HPLC with triple quadrupole mass spectrometry (HPLC-ESI-QqQ-MS/MS) operating in multiple reaction monitoring (MRM) mode.
  • Tablet formulations by reversed phase (RP) HPLC with ultraviolet (UV) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

hcodes

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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Certificates of Analysis (COA)

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Chromatographic separation of racemic praziquantel and its residual determination in perch by LC-MS/MS.
He L, et al.
Talanta, 174, 380-386 (2017)
Development and validation of a dissolution test method for albendazole and praziquantel in their combined dosage form.
Vignaduzzo S, et al.
Journal of the Brazilian Chemical Society, 26(4), 729-735 (2015)
Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.
Meister I, et al.
Journal of Pharmaceutical and Biomedical Analysis, 118, 81-88 (2016)
A rapid stability indicating LC-method for determination of praziquantel in presence of its pharmacopoeial impurities.
Hashem H, et al.
Arabian Journal of Chemistry, 10, S35-S41 (2017)
Study of praziquantel phytoremediation and transformation and its removal in constructed wetland.
Marsik P, et al.
Journal of Hazardous Materials, 323, 394-399 (2017)

Protocols

Praziquantel Determination in Aquarium Water - Learn how the use of a Chromolith® monolithic silica column allows simplification of sample preparation.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service