Skip to Content
MilliporeSigma
All Photos(1)

Documents

52517

Supelco

1,1,1,3,3,3-Hexafluoro-2-propanol

for GC derivatization, LiChropur™, ≥99.8%

Synonym(s):

HFP, Hexafluoroisopropanol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
920-66-1
Molecular Weight:
168.04
Beilstein/REAXYS Number:
1841007
EC Number:
213-059-4
MDL number:
MFCD00011651
UNSPSC Code:
12352104
PubChem Substance ID:
329757847
NACRES:
NA.05

grade

for GC derivatization

Quality Level

100

assay

≥99.8% (GC)
≥99.8%

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

SMILES string

OC(C(F)(F)F)C(F)(F)F

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Hexafluoroisopropanol (HFP) is generally used to denature the native state of proteins, and it also stabilizes the a-helical conformation in unfolded peptides and proteins like ß-lactoglobulin and melittin.

Application

Suitable for the derivatization of glutamic acid, homovanillic, iso-homovanillic and dihydroxyphenyl acetic acids and Υ-aminobutyric acid.

Other Notes

Reagent for hexafluoroisopropyl ester, N-pentafluoropropionyl, and trifluoroacetyl..
Size-exclusion chromatography in 1,1,1,3,3,3-hexafluoro-2-propanol

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2

wgk_germany

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

Faceshields, Gloves, Goggles

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 4

1 of 4

Triethylamine suitable for HPLC, LiChropur™, ≥99.5% (GC)

Supelco

81101

Triethylamine

1,1,1,3,3,3-Hexafluoro-2-propanol-OD 98 atom % D

Sigma-Aldrich

411302

1,1,1,3,3,3-Hexafluoro-2-propanol-OD

2,2,3,3,3-Pentafluoro-1-propanol for GC derivatization, LiChropur™, ≥98.5% (GC)

Supelco

79879

2,2,3,3,3-Pentafluoro-1-propanol

β Amyloid 1-42, aβ, ultra pure, HCl, recombinant human

Sigma-Aldrich

AG972

β Amyloid 1-42, aβ, ultra pure, HCl, recombinant human

Thomas H Mourey et al.
Journal of chromatography. A, 964(1-2), 169-178 (2002-08-30)
1,1,1,3,3,3-Hexafluoroisopropanol is re-examined as an eluent for size-exclusion chromatography (SEC) of polyesters, nylons, and other polar polymers. It is shown that anomalous SEC behavior reported in previous literature can be eliminated by adding 0.01 M tetraethylammonium nitrate to the eluent.
Cooperative a-helix formation of ?-lactoglobulin and melittin induced by hexafluoroisopropanol
Hirota, Nami, Yuji Goto, and Kazuko Mizuno.
Protein Science, 6 (2), 416-421 (1997)
Sriya Das et al.
ACS applied materials & interfaces, 3(6), 1844-1851 (2011-05-05)
We demonstrate a novel in situ polymerization technique to develop localized polymer coatings on the surface of dispersed pristine graphene sheets. Graphene sheets show great promise as strong, conductive fillers in polymer nanocomposites; however, difficulties in dispersion quality and interfacial
Dave W Chen et al.
International journal of pharmaceutics, 430(1-2), 335-341 (2012-04-24)
This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/vancomycin/gentamicin/lidocaine were separately dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). They were then electrospun into
Benjamin H Rotstein et al.
Chemical communications (Cambridge, England), 48(31), 3775-3777 (2012-03-21)
A novel class of reagents, thioester isocyanides, have been prepared and applied in the synthesis of peptide macrocycles. The isocyanide part of the molecule is deployed in a multicomponent macrocyclization step. This step is followed by chemoselective peptide ligation at
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service