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α-Ketoglutaric acid

analytical standard

Synonym(s):

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
Molecular Weight:
146.10
Beilstein/REAXYS Number:
1705689
EC Number:
MDL number:
UNSPSC Code:
41116107

grade

analytical standard

assay

99.0-101.0% (T)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

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General description

α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling. It plays an important role in living beings as an angiogenesis suppressor.

Application

α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human plasma samples using gas-chromatography coupled to mass spectrometry.
  • Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  • Fruits and vegetables using HPLC-MS/MS.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Simultaneous quantitative determination of ?-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography?mass spectrometry
Wagner MB, et al.
Analytical and Bioanalytical Chemistry, 396(7), 2629-2637 (2010)
Gas chromatographic profiling and pattern recognition analysis of urinary organic acids from uterine myoma patients and cervical cancer patients
Kim R-K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 712(1-2), 11-22 (1998)

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