917850
tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
≥95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C18H27NO3
CAS Number:
Molecular Weight:
305.41
MDL number:
UNSPSC Code:
12352116
Recommended Products
Quality Level
assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
Boc
hydroxyl
storage temp.
2-8°C
SMILES string
O=C(N(CC1)CCC1C2=C(CCO)C=CC=C2)OC(C)(C)C
Application
tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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Product No.
Description
Pricing
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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